An emerging family of dual specificity MAP kinase phosphatases
نویسندگان
چکیده
منابع مشابه
Dual-specificity MAP kinase phosphatases (MKPs)
Dual-specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase activities in response to both physiological and pathological stimuli. Individual MKPs may exhibit either exquisite specificity towards a single mitogen-activated protein kinase (MAPK) isoform or be able to regulate mul...
متن کاملDiverse physiological functions for dual-specificity MAP kinase phosphatases.
A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals. These MAPK phosphatases (MKPs) interact specifically with their substrates through a modular kinase-interaction motif (KIM) located within the N-terminal non-catalytic do...
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Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of physiological and pathological changes in cell function. MAP kinase activation requires phosphorylation on a threonine and tyrosine residue located within the activation loop of kinase subdomain VIII. This process is reversible even in the continu...
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The dual specificity phosphatases (DUSPs) are a subfamily within the protein tyrosine phosphatase (PTP) family, with the unique property of being able to hydrolyze phosphoserine or phospho-threonine residues and phospho-tyrosine residues [1]. All DUSPs share the characteristic Class I PTP consensus sequence, D...HC(X)5RS/T, with C representing the essential catalytic cysteine [1]. Unlike other ...
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Intracellular signaling by mitogen-activated protein (MAP) kinases (MAPK) is involved in many cellular responses and in the regulation of various physiological and pathological conditions. Tight control of the localization and duration of extracellular-regulated kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), or p38 MAPK activity is thus a fundamental aspect of cell biology. Several members of...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1995
ISSN: 0167-4889
DOI: 10.1016/0167-4889(94)00211-v